There is a growing body of evidence demonstrating the evidence of spinal manipulation (SM) for the treatment of low back and neck pain.  While it has been demonstrated to be clinically effective, the exact mechanism through which SM exerts if effect remains uncertain.  Generally, SM is believed to create a number of neurophysiological changes in the body by affecting the peripheral and autonomic nervous systems, as well as the endocrine system. With respect to the sensation of pain, nociception at the site of injury is mediated by locally and remotely produced biochemical markers, such as neurotensin, oxytocin and substance-P (SP), which transmit the signal from the area of injury to the nervous system.  These biochemical markers are also related to the initiation of the inflammatory response at the site of injury, which leads to the production of proinflammatory and immunoregulatory cytokines and neurotransmitters such as tumour necrosis factor α (TNF-α), interleukins (IL), endogenous opioids, hormones and catecholamines).

 
While it has been hypothesized that SM activates the release of biochemical markers from neural tissue, no systematic review has evaluated the strength of this evidence.  The objective of the current systematic review (published in Musculoskeletal Science & Practice 2017)was to determine the effects of SM on biochemical markers in humans and establish the level of evidence for changes in biochemical biomarkers following SM…LOG IN OR SUBSCRIBE TO ACCESS THE FULL REVIEW!
 
 
Biochemistry

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